With the Denver Broncos and New York Jets set to clash on Thursday Night Football, Week 4 of the NFL season is officially here. Looking for a one-stop shop when it comes to predictions on the gridiron this week? You’ve come to the right place.
Our NFL Betting Guide is here to break down the upcoming matchups to assist you in your handicapping. For outright Super Bowl 55 odds, check out our Super Bowl Futures article. To find the sportsbook that’s right for you when it comes to NFL betting, visit our Best NFL Sites page.
Odds courtesy of Bovada
Indianapolis Colts vs Chicago Bears +3, 43
Prediction: Indianapolis 28, Chicago 17
Week 4’s clash against the Colts marks the first as a starter for Nick Foles in a Bears uniform. Foles came on in relief of the embattled Mitchell Trubisky in Week 3 and guided the Bears to a come-from-behind win over the Atlanta Falcons, so momentum is on his side right now.
The improved Colts defense ranks as one of the toughest units in the league against quarterbacks, so this is not a great spot for Foles and the Bears offense as a whole. Look for Jonathan Taylor to have a big day en route to the Colts handing the Bears their first loss of the season.
Cleveland Browns vs Dallas Cowboys -4, 56
Prediction: Dallas 32, Cleveland 20
The Cowboys are better than their 1-2 record indicates, but they’ve been far from a consistent team through three games – especially when it comes to betting them on the spread.
Dallas’s defense has been less than impressive so far, which could be a problem against the running back duo of Nick Chubb and Kareem Hunt. Dak Prescott will likely have to take control of this game in the second half, and I expect him to do just that with the litany of talented receivers at his disposal.
Minnesota Vikings vs Houston Texans -3.5, 53.5
Prediction: Minnesota 30, Houston 27
In another matchup between 0-3 teams, the Vikings and Texans head into a Week 4 matchup with both of their seasons seemingly already on the brink. Houston has played an incredibly tough schedule so far, while Minnesota has no excuses for its winless record.
It’s far from a safe bet, but I’m on the Vikings to win outright as road underdogs. Kirk Cousins has looked very beatable this season but I think this is a get-right game for him against a Texans defense that’s been less than stellar.
New Orleans Saints vs Detroit Lions +3, 54
Prediction: New Orleans 20, Detroit 14
The Saints didn’t look good in a home prime-time loss to the Green Bay Packers last week, as the absence of star wide receiver Michael Thomas was evident.
New Orleans goes up against a Detroit team that’s coming off a victory over the Arizona Cardinals, but I can’t see the Lions rattling off two wins in a row given their inconsistency under head coach Matt Patricia. Drew Brees and the Saints should bounce back in this game and take advantage of an underwhelming Lions defense.
Arizona Cardinals vs Carolina Panthers +3, 51.5
Prediction: Arizona 27, Carolina 14
The Cardinals are a better team than they showed last week against the Lions. Don’t be surprised if a different Cardinals squad shows up in Week 4 and takes out some anger on a talent-depleted Panthers team.
Kyler Murray and DeAndre Hopkins are the best one-two punch in the NFL right now at the quarterback and wide receiver positions. If Christian McCaffrey was playing, I’d bank on this being a much closer game, but since he’s out with an injury, I’m going to fade Carolina and take the Cards to win outright on the road.
Baltimore Ravens vs Washington Football Team +14, 45
Prediction: Baltimore 31, Washington 13
The Ravens are coming off a major letdown against the Kansas City Chiefs on Monday Night Football, and while Lamar Jackson’s MVP odds have tumbled over the past week, this is a get-right game for Baltimore to get back to its usual high-scoring ways.
Washington is going to have a tough time keeping up against the Ravens offense, so don’t be surprised if this one is over by halftime.
Los Angeles Chargers vs Tampa Bay Buccaneers -7, 42
Prediction: Tampa Bay 24, Los Angeles 20
Tom Brady is a 20-year veteran in this league, while Justin Herbert has only two games under his belt. Experience is worth a lot in this league, and Brady has it in spades. Bettors are clearly expecting a Tampa Bay win here, as this game has experienced the most line movement of the week.
The Chargers defense is solid, but the Tampa Bay defensive unit has been one of the biggest surprises of the season. The Buccaneers have a major edge on offense and that’s going to be the difference in this one.
Seattle Seahawks vs Miami Dolphins +5.5, 55
Prediction: Seattle 40, Miami 28
Seattle has been winning games by airing out the football, and Russell Wilson’s case for MVP will continue to be made in Week 4 against the lowly Dolphins.
The only edge the Fins have in this game is travel and rest, as the Dolphins will be well-rested after their Week 3 TNF matchup. It doesn’t matter from which part of the country or how far they have to travel – the Seahawks are for real. Seattle will continue to show in South Beach why it’s third on the Super Bowl oddsboard.
Jacksonville Jaguars vs Cincinnati Bengals -2.5, 49
Prediction: Cincinnati 17, Jacksonville 14
A pair of young QBs will go head-to-head in a battle between teams that are expected to be on the outside of the playoff picture. Joe Burrow has been the lone bright spot for the Bengals, while Gardner Minshew is in line to put forth a better performance than he did in Week 3 if D.J. Chark is back in the fold.
The Jaguars are having problems on defense, so this looks like a great spot for Burrow to air it out. Cincy’s biggest issue is its offensive line, yet the Jags’ pass rush is not exactly one to be feared. The Bengals take this one in a sloppy game.
New York Giants vs Los Angeles Rams -13.5, 48.5
Prediction: Los Angeles 36, New York 6
The loss of Saquon Barkley for the season was a dagger to the hearts of Giants fans, but even with a healthy Barkley, this team wasn’t going to be a playoff contender. New York now faces a tough road test against a good Rams team that nearly beat the Buffalo Bills in Week 3, and the Giants are almost two-touchdown underdogs.
The Rams defense hasn’t lived up to its billing so far in 2020, but Aaron Donald is in line for a huge performance against the Giants’ weak offensive line. L.A. lands up an easy win here.
Buffalo Bills vs Las Vegas Raiders +3, 53
Prediction: Buffalo 37, Las Vegas 21
The Bills look like one of the main contenders in the AFC right now and have a great opportunity to improve to 4-0 against Las Vegas this weekend. Josh Allen has silenced his critics and has improved his accuracy, and Stefon Diggs looks like the No. 1 wide receiver the Bills have been needing.
I think the Bills should be bigger favorites here. Playing on the road in the NFL is never easy, but with the lack of fans in the COVID-19 era, home-field advantage is not what it used to be. Bills win big.
Philadelphia Eagles vs San Francisco 49ers -7.5, 45
Prediction: San Francisco 26, Philadelphia 13
The Eagles have been one of the biggest disappointments in the NFL through three weeks. Carson Wentz looks bad, the offensive line is a mess and Wentz’s receivers can’t stay healthy. Philly has clearly lost the respect of both bettors and oddsmakers, and it’s hard to foresee the Eagles covering the +7.5 number here.
San Francisco has some major injury issues of its own, but it won’t matter in this game. Nick Mullens is far from a superstar but he’s shown to be a capable quarterback in the past. The Niners defense is primed for a big day against the hapless Eagles, so expect Philly to once again struggle to put points on the board in Week 4.
Atlanta Falcons vs Green Bay Packers -7, 56.5
Prediction: Green Bay 40, Atlanta 26
The winless Falcons are coming off two huge chokes in their past two games. The seat under Dan Quinn continues to get hotter, and rumors about him losing his job if the Falcons don’t turn it around quickly are hard to ignore.
Things won’t get any easier against the undefeated Packers. Green Bay boasts one of the best offenses in the league and showed it can win without star WR Davante Adams in a victory over the Saints last week. Green Bay’s defense is a concern, but Aaron Rodgers and Aaron Jones will do enough damage on offense to hand the Falcons their fourth loss of the young campaign.